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Unmet Need in Obesity

Obesity is one of the world’s largest health challenges affecting a substantial portion of the global population.

Obesity is one of the world’s largest health challenges affecting a substantial portion of the global population.

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More than two thirds of Americans are overweight or obese. On a global level, more than 1.9 billion adults are overweight, of whom 600 million are obese. Current approaches to treating obesity include surgery and drugs, which have unwanted adverse events and/or limited efficacy. Due to the safety profile of current interventions, we believe that doctors are particularly reticent to prescribe these therapies to their patients. Our view is that a clear unmet need exists for an orally dosed, safe, and efficacious therapy to induce weight loss in overweight and obese patients.



Unmet Need in Diabetes

Type 2 diabetes is the result of a high level of glucose in a person’s bloodstream due to their resistance to insulin, the hormone that regulates blood sugar.

Excess weight is linked with developing type 2 diabetes.

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US Adults are pre-diabetic.

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Diabetes is marked by abnormally high blood glucose levels which, if left untreated, can lead to serious complications including death. Type 2 diabetes, which accounts for approximately 90% of diabetics, was previously found nearly always in adults, but can now be found in pediatric populations. There are ~26 million Americans that have type 2 diabetes and there are a total of ~312 million people who have type 2 diabetes on a global basis.

Pre-diabetes is a state where blood glucose levels are elevated above normal ranges, but have not yet reached the point where the patient is considered diabetic. Pre-diabetics are at great risk for developing diabetes. There are ~86 million adults in the US who have pre-diabetes.

Obesity is a major risk factor for developing pre-diabetes and diabetes. Approximately 85% of type 2 diabetics are overweight or obese. Losing weight is clearly beneficial for both pre-diabetic and diabetic subjects. For instance, 5-7% weight loss can prevent conversion from pre-diabetes to diabetes in ~58% of patients. Given the costs associated with treating diabetes, a safe, effective treatment that could cause weight loss in pre-diabetics would not only have a potentially major impact on human health but may also result in tremendous savings for the healthcare system.



Health Resources

For more information regarding obesity and type 2 diabetes, please visit:


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